PROEFSCHRIFTEN
Genetic and environmental determinants of cardiometabolic health
Genetic and environmental determinants of cardiometabolic health Doctoral thesis | Bos, M.M.(2020) Cardiovascular disease and diabetes are one of the leading causes of death worldwide. Multiple genetic and non-genetic factors play a role in this process. This dissertation aims to study the interplay between genetic factors and lifestyle factors (eg sleep, nutrition, physical [...]
The endocrinology of familial longevity : time series analyses of different hormonal axes and their interrelationships
The endocrinology of familial longevity : time series analyses of different hormonal axes and their interrelationships Doctoral thesis | Spoel, E. van der(2019) Maintenance and repair is of key importance for the proper functioning of cells, tissues, and integrated physiology. We hypothesize that the balance between investments in growth, development, and reproduction versus [...]
The role of inflammation in muscle aging
The role of inflammation in muscle aging Doctoral thesis | Beenakker, K.G.M.(2017) The aim of this thesis is to investigate the role of chronic inflammation as well as acute inflammatory response on muscle aging. We conclude that high chronic inflammation is associated with low muscle strength, while high acute pro-inflammatory response is associated [...]
Human longevity : crosstalk between the brain and periphery
Human longevity : crosstalk between the brain and periphery Doctoral thesis | Akintola, A.A.(2016) Although mortality in old age has significantly decreased over the last fifty years in the developed world, there still remains a large inter-individual variability in ageing trajectories, morbidity and mortality. In the three parts of this thesis, we examined three [...]
The skin as a mirror of the aging process
The skin as a mirror of the aging process Doctoraal thesis | Waaijer, M.E.C.(2016) This thesis describes to which extent the skin reflects the aging process, with a specific focus on cellular senescence. Since the first descriptions of the growth arrested state of fibroblasts upon multiple replication rounds, cellular senescence has now emerged [...]
Pituitary hormone secretion in familial longevity : The Switchbox Study
Pituitary hormone secretion in familial longevity : The Switchbox Study Doctoral Thesis | Jansen, Wilhelmina Maria (2016) The overall hypothesis of the Switchbox study is that maintenance of homeostasis is pivotal for maintenance of health in old age. Therefore, the aim of this thesis as part of the Switchbox study, was to expand our [...]